Jun and JunD-dependent functions in cell proliferation and stress response
نویسندگان
چکیده
منابع مشابه
JunD regulates lymphocyte proliferation and T helper cell cytokine expression.
Transgenic mice broadly expressing JunD (Ubi-junD(m)) appear phenotypically normal, but have strongly reduced numbers of peripheral lymphocytes. JunD overexpression in lymphocytes does not protect from numerous apoptotic insults; however, transgenic T cells proliferate poorly and exhibit impaired activation due to reduced levels of IL-4, CD25 and CD69. Consistently, in the absence of JunD (junD...
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15 صفحه اولC-Jun and JunD suppress maturation of chondrocytes.
To analyze the function of AP-1 in cartilage formation, two types of primary chondrocytes, LS and US cells, were prepared from caudal (lower) and cephalic (upper) regions of chicken sterna, respectively. All the known components of chicken AP-1 (c-Fos, Fra-2, c-Jun, and JunD) were detected in both cell types, but the expression level of c-Jun was much higher in LS cells, which are rich in less ...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2010
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2010.22